Andreessen Horowitz to Open Regional Headquarters in West Palm Beach

South Florida Business Journal, September 10, 2026

One of the world’s largest venture capital firms will establish a regional headquarters in South Florida for a billion-dollar fund focused on defense investments.

Menlo Park, California-based Andreessen Horowitz, also known as a16z, said Thursday it would open a regional headquarters for its $1.18 billion American Dynamism fund in West Palm Beach.

When reached by the Business Journal, a spokesperson for West Palm Beach-based Related Ross confirmed the firm signed a long-term lease for office space in CityPlace Tower, at 525 Okeechobee Blvd., with move-in slated for early 2027.

“Our decision to establish a regional headquarters in West Palm Beach reflects our belief that many of tomorrow’s breakthrough American Dynamism companies will be built here in Florida. We want to be on the ground alongside the founders building them,” Katherine Boyle, general partner and co-founder of the American Dynamism practice, said in a news release.

Other details, including the size of the new office and potential plans for local hires, weren’t immediately available. This would be Andreessen Horowitz’s sole South Florida location and the first dedicated office for the firm’s American Dynamism fund, a representative confirmed to the Business Journal.

The deal marks a major win for efforts by Stephen Ross, Related Ross’ billionaire CEO and chairman and owner of the Miami Dolphins, to attract major corporations to South Florida and grow the tri-county region’s profile in defense and technology.

Last October, Related Ross helped launch a program to incubate defense and financial technology startups in South Florida. A few months later, Ross, together with Miami-based Citadel founder and CEO Ken Griffin, announced a $10 million campaign to attract more national business leaders to the tri-county region.

“Our goal has always been to help build South Florida into a place where the world’s most ambitious companies, founders and investors can build for the long term,” Ross said in a release. “Andreessen Horowitz establishing their American Dynamism regional headquarters in West Palm Beach is an important step toward that objective.”